Optimizing Activin Pathway Inhibition For Obesity – Regulation of Adipose, Liver, & Muscle Metabolism
Time: 1:30 pm
day: Pre-Conference Day
Details:
- TGFb superfamily signaling through the Activin receptor type II (ACTRII) selectively regulates metabolism in multiple tissues, including adipose and muscle
- In both DIO mice and human patients, ACTRII inhibition reduces fat mass while supporting preservation or growth of muscle mass
- Oral small molecule inhibitors of ACTRII have distinct effects from biologic inhibitors, likely driven by PK and biodistribution, that offer unique clinical potential both as monotherapy and in combination with GLP-1 agonists
Speakers:
