Role of Notch-Inhibiting Nanoparticles in the Browning and Activation of White Adipose Tissue to Boost Resting Metabolic Rate and Increase Energy Expenditure

Time: 2:00 pm
day: Pre-Conference Day

Details:

• Browning of white adipose tissue can be accomplished with Notch-inhibition which induces mitochondrial biogenesis and mitochondrial activation
• Notch-inhibiting NP have demonstrated weight loss and a decrease in blood glucose and lipids in rodents
• Human ex vivo fat studies support potential for clinical translation of Notch-inhibition in adults with obesity
• Minimal off-target impact and associated side effects possible through local delivery of PLGA nanoparticles

Speakers:

Tom Hardy Thomas Hardy, MD, PhD is Chief Medical Officer at Adipo Therapeutics. Dr. Hardy is an Endocrinologist with over 20 years of experience in clinical research Read more