Recapitulating Skeletal Muscle Atrophy, Insulin Sensitivity, and Metabolism in a 3D Human Engineered Tissue Platform
Time: 11:20 am
day: Day One
Details:
- Presents a sophisticated commercialized 3D human engineered muscle tissue (EMT) platform that overcomes the limitations of traditional models for studying human skeletal muscle
- Enables simultaneous longitudinal, non-destructive measurements of contractile force and biochemical (metabolic) analyses
- Demonstrates the ability to recapitulate Activin A-induced functional atrophy (reduced twitch force and size), differential insulin sensitivity, physiologic metabolic responses (e.g., modulating glycogen and exercise-induced lactate)
- Provides a powerful framework for metabolic drug discovery to evaluate therapeutic efficacy while de-risking treatment-induced sarcopenia
